NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation V368R was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation V368R in RORA_HUMAN

Point mutation:	V368R
Cited point mutation:	V335R
Domain:	LBD HELIX 3
General numbering (NucleaRDB):	347
Protein:	RORA_HUMAN (RORA,NR1F1, RZR)	Swiss-Prot Cross-reference table Family page
Protein isoforms	4
Other point mutations / same protein	List of mutations in RORA_HUMAN
Family alignments	1F1 ROR alpha 1F RAR-related orphan receptor (ROR,HR3) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position	Position 230 in 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR family
Reference:	Coactivators for the orphan nuclear receptor RORalpha. Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA Mol Endocrinol 1999 Sep;13(9):1550-7.	Medline
Other point mutations / same article	List
Text source	HTML and PDF full texts
Validation status	True positive

Relevant sentences:

V335R

The mutations used , V335R and LF510AA , are analogous to mutations in the GRIP-1 interaction surface of TR that have been shown to abrogate ligand-dependent TR activation and interaction with GRIP-1 (25 )

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005