NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation M340T was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation M340T in NR1I3_HUMAN

Point mutation:	M340T
Cited point mutation:	Met340Thr,Met340
Domain:	Loop 11-12
General numbering (NucleaRDB):	-
Protein:	NR1I3_HUMAN (NR1I3,CA)	Swiss-Prot Cross-reference table Family page
Protein isoforms	2
Other point mutations / same protein	List of mutations in NR1I3_HUMAN
Family alignments	1I3 Constitutive Androstane alpha (CAR1) 1I Vitamin D3-like (VDR,PXR,CAR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position	Position 394 in 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR family
Reference:	Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR. Ueda A, Kakizaki S, Negishi M, Sueyoshi T Mol Pharmacol 2002 Jun;61(6):1284-8.	Medline
Other point mutations / same article	List
Text source	HTML and PDF full texts
Validation status	True positive

Relevant sentences:

M340T

Substituting Met340 with threonine (hCAR M340T) did not alter the nonresponsiveness of the human receptor to steroid hormones (Fig. 2 , A and B)

Met340

Alignment of 13 residues with the corresponding residues of hCAR (from positions 336 to 348) revealed two amino acid differences: Thr350 and Gly354 of mCAR were substituted in hCAR with Met340 and Gln344 , respectively
Substituting Met340 with threonine (hCAR M340T) did not alter the nonresponsiveness of the human receptor to steroid hormones (Fig. 2 , A and B)
Met340 in hCAR was also mutated to Thr

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005