NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation E355A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation E355A in NR1I3_MOUSE

Point mutation:	E355A
Cited point mutation:	Glu355Ala
Domain:	LBD HELIX 12
General numbering (NucleaRDB):	1250
Protein:	NR1I3_MOUSE (Nr1i3,Ca)	Swiss-Prot Cross-reference table Family page
Protein isoforms	2
Other point mutations / same protein / same position	Point mutations at position 355 in NR1I3_MOUSE
Other point mutations / same protein	List of mutations in NR1I3_MOUSE
Family alignments	1I3 Constitutive Androstane alpha (CAR1) 1I Vitamin D3-like (VDR,PXR,CAR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position	Position 355 in 1I3 Constitutive Androstane alpha (CAR1) family Position 415 in 1I Vitamin D3-like (VDR,PXR,CAR) family Position 403 in 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR family
Reference:	Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR. Ueda A, Kakizaki S, Negishi M, Sueyoshi T Mol Pharmacol 2002 Jun;61(6):1284-8.	Medline
Other point mutations / same article	List
Text source	HTML and PDF full texts
Validation status	True positive

Relevant sentences:

Glu355Ala

mCAR lost its constitutive activity after an AF2 mutation (Leu352Ala or Glu355Ala) or an AF2 deletion in a cell-based transfection assay (Choi et al. , 1997(image) )
mCAR lost its constitutive activity after an AF2 mutation (Leu352Ala or Glu355Ala) or an AF2 deletion in a cell-based transfection assay (Choi et al. , 1997)

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005