NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation L506A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation L506A in O77255_CHOFU

Point mutation:	L506A
Domain:	Loop 11-12
General numbering (NucleaRDB):	-
Protein:	O77255_CHOFU (non)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein	List of mutations in O77255_CHOFU
Family alignments	1H1 Ecdysone 1H Ecdysone-like (ECR,LXR,FXR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position
Reference:	A single point mutation in ecdysone receptor leads to increased ligand specificity: implications for gene switch applications. Kumar MB, Fujimoto T, Potter DW, Deng Q, Palli SR Proc Natl Acad Sci U S A 2002 Nov 12;99(23):14710-5.	Medline
Other point mutations / same article	List
Text source	PDF full text
Validation status	True positive

Relevant sentences:

L506A

Transactivation and binding activity of CfEcR mutants Amino acid % WT activity % WT RH-2485 binding RG-102240 (2.5 M) PonA (2.5 M) Y120A (Y403A) 0.05 0.33 6.3 W238A (W521A) 0.06 0.44 2.6 L234A (L517A) 0.07 0.31 1.5 L230A (L513A) 0.08 0.34 8.6 I51A (I334A) 0.26 0.27 10.2 M125A (M408A) 0.30 0.36 5.9 F48A (F331A) 0.41 0.38 0.0 A123F (A406F) 7.6 0.33 0.0 L223A (L506A) 9.3 0.45 40.4 F109A (F392A) 22.2 0.32 52.8 T55A (T338A) 25.1 1.29 33.9 R95A (R378A) 33.7 0.38 105.7 M93A (M376A) 38.3 3.70 0.0 T58A (T341A) 34.9 55.0 58.8 A110P (A393P) 69.7 0.33 105.6 M92A (M375A) 70.0 39.0 84.0 E20A (E303A) 149.0 108.0 83.6 CfEcR mutants were assayed in 3T3 cell transactivation assay and ligandbinding assay as described in Materials and Methods

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005