NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation C229A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation C229A in NR1I3_MOUSE

Point mutation:	C229A
Domain:	Loop 5-6
General numbering (NucleaRDB):	-
Protein:	NR1I3_MOUSE (Nr1i3,Ca)	Swiss-Prot Cross-reference table Family page
Protein isoforms	2
Other point mutations / same protein	List of mutations in NR1I3_MOUSE
Family alignments	1I3 Constitutive Androstane alpha (CAR1) 1I Vitamin D3-like (VDR,PXR,CAR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position	Position 283 in 1I Vitamin D3-like (VDR,PXR,CAR) family Position 276 in 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR family
Reference:	The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor. Andersin T, Vaisanen S, Carlberg C Mol Endocrinol 2003 Feb;17(2):234-46.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	True positive

Relevant sentences:

C229A

Using the PBREM reporter gene construct in MCF-7 cells as a probe for CAR signaling (Fig. 6(image) ) , the first hypothesis could not be proven , since the ligand response profile of both C229A and C233A was found to be very similar to that of wild-type CAR (Fig. 6A(image) )

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005