NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation P12A was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation P12A in PPAT_HUMAN

Point mutation:	P12A
Cited point mutation:	Pro12Ala
Domain:	N-term
General numbering (NucleaRDB):	-
Protein:	PPAT_HUMAN (PPARG,NR1C)	Swiss-Prot Cross-reference table Family page
Protein isoforms	2
Other point mutations / same protein / same position	Point mutations at position 12 in PPAT_HUMAN
Other point mutations / same protein	List of mutations in PPAT_HUMAN
Family alignments	1C3 PPAR gamma 1C Peroxisome proliferator activated (PPAR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position
Reference:	The Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men. Rosmond R, Chagnon M, Bouchard C Diabetes Metab Res Rev 2003 Mar-Apr;19(2):159-63.	Medline
Other point mutations / same article	List
Text source	HTML full text
Validation status	True positive

Relevant sentences:

Pro12Ala

The Pro12Ala PPAR(image)2 polymorphism has been variably associated with obesity , insulin sensitivity , and dyslipidemia
Aims and methodsIn the present study , we addressed the hypothesis that the Pro12Ala variant is associated with obesity and estimates of insulin , glucose , and lipid metabolism as well as circulating hormones including salivary cortisol in 284 unrelated Swedish men born in 1944

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005