NucleaRDB: Extraction of mutation data from the literature

2005, NucleaRDB.

This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes the selected point mutation and provides links to other documents. The sentence(s) where the point mutation E457R was found are listed after the table.

The mutated residues are also indicated in the family sequence alignments and hyperlinked to the corresponding mutation pages.

Point mutation E457R in THB1_HUMAN

Point mutation:	E457R
Domain:	LBD HELIX 12
General numbering (NucleaRDB):	1250
Protein:	THB1_HUMAN (THRB,ERBA2, NR1A2, THR)	Swiss-Prot Cross-reference table Family page
Other point mutations / same protein / same position	Point mutations at position 457 in THB1_HUMAN
Other point mutations / same protein	List of mutations in THB1_HUMAN
Family alignments	1A2 Thyroid hormone beta 1A Thyroid hormone (TR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations / same position	Position 403 in 1A2 Thyroid hormone beta family Position 403 in 1A Thyroid hormone (TR) family Position 403 in 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR family
Reference:	A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators. Tagami T, Gu WX, Peairs PT, West BL, Jameson JL Mol Endocrinol 1998 Dec;12(12):1888-902.	Medline
Other point mutations / same article	List
Text source	HTML and PDF full texts
Validation status	True positive

Relevant sentences:

E457R

Another mutant , E457R , also exhibited strong interactions with NCoR (data not shown) , suggesting that the type of amino acid substitution , as well as its location in the AF-2 domain , may influence interactions with NCoR

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005