NucleaRDB: Point mutations extracted from the literature - NR1H3_HUMAN

2005, NucleaRDB.

This data was extracted from medline abstracts and full text papers (when available) in an automated manner.

Each point mutation is linked to the entry specific to the residue position. Citations are linked to the list of point mutations found in the corresponding articles. The last column allows you to go back to the original text via Medline.

Protein	NR1H3_HUMAN (NR1H3,LXR)	Swiss-Prot Cross-reference table Family page
Protein isoforms	2
Family alignments	1H3 Oxysterol LXR alpha 1H Ecdysone-like (ECR,LXR,FXR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR

Mutation Location General numbering Reference
F254A LBD HELIX 3 332 Wang M et al., J Mol Graph Model 2003 Medline

F257A LBD HELIX 3 335 Wang M et al., J Mol Graph Model 2003 Medline

M298A LBD HELIX 5 552 Wang M et al., J Mol Graph Model 2003 Medline

L299A LBD HELIX 5 553 Wang M et al., J Mol Graph Model 2003 Medline

E301A LBD HELIX 5 555 Wang M et al., J Mol Graph Model 2003 Medline

T302A LBD HELIX 5 556 Wang M et al., J Mol Graph Model 2003 Medline

R305L LBD HELIX 5 559 Wang M et al., J Mol Graph Model 2003 Medline

F315A Loop 5-6 Wang M et al., J Mol Graph Model 2003 Medline

L316A Loop 5-6 Wang M et al., J Mol Graph Model 2003 Medline

L331A Loop 6-7 Wang M et al., J Mol Graph Model 2003 Medline

F335A LBD HELIX 7 738 Wang M et al., J Mol Graph Model 2003 Medline

H421A LBD HELIX 10-11 1057 Wang M et al., J Mol Graph Model 2003 Medline

Q424A LBD HELIX 10-11 1060 Wang M et al., J Mol Graph Model 2003 Medline

L439A LBD HELIX 12 1248 Wang M et al., J Mol Graph Model 2003 Medline

I442A LBD HELIX 12 1251 Wang M et al., J Mol Graph Model 2003 Medline

W443Y LBD HELIX 12 1252 Wang M et al., J Mol Graph Model 2003 Medline

Mutation	Location	General numbering	Reference
F254A	LBD HELIX 3	332	Wang M et al., J Mol Graph Model 2003	Medline
F257A	LBD HELIX 3	335	Wang M et al., J Mol Graph Model 2003	Medline
M298A	LBD HELIX 5	552	Wang M et al., J Mol Graph Model 2003	Medline
L299A	LBD HELIX 5	553	Wang M et al., J Mol Graph Model 2003	Medline
E301A	LBD HELIX 5	555	Wang M et al., J Mol Graph Model 2003	Medline
T302A	LBD HELIX 5	556	Wang M et al., J Mol Graph Model 2003	Medline
R305L	LBD HELIX 5	559	Wang M et al., J Mol Graph Model 2003	Medline
F315A	Loop 5-6		Wang M et al., J Mol Graph Model 2003	Medline
L316A	Loop 5-6		Wang M et al., J Mol Graph Model 2003	Medline
L331A	Loop 6-7		Wang M et al., J Mol Graph Model 2003	Medline
F335A	LBD HELIX 7	738	Wang M et al., J Mol Graph Model 2003	Medline
H421A	LBD HELIX 10-11	1057	Wang M et al., J Mol Graph Model 2003	Medline
Q424A	LBD HELIX 10-11	1060	Wang M et al., J Mol Graph Model 2003	Medline
L439A	LBD HELIX 12	1248	Wang M et al., J Mol Graph Model 2003	Medline
I442A	LBD HELIX 12	1251	Wang M et al., J Mol Graph Model 2003	Medline
W443Y	LBD HELIX 12	1252	Wang M et al., J Mol Graph Model 2003	Medline

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005