NucleaRDB: Point mutations extracted from the literature - RXRA_HUMAN

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This data was extracted from medline abstracts and full text papers (when available) in an automated manner.

Each point mutation is linked to the entry specific to the residue position. Citations are linked to the list of point mutations found in the corresponding articles. The last column allows you to go back to the original text via Medline.

ProteinRXRA_HUMAN (RXRA,NR2B)Swiss-Prot
Cross-reference table
Family page
Family alignments 2B1 RXR alpha
2B Retinoic acid X (RXR,USP)
2 HNF4-like (HNF4,RXR,TLL,COUP,USP)

MutationLocationGeneral numberingReference
T82AN-term Matsushima-Nishiwaki R et al., Cancer Res 2001Medline
T82DN-term Matsushima-Nishiwaki R et al., Cancer Res 2001Medline
T168PDNA_BINDD034Ribeiro RC et al., J Biol Chem 2001Medline
Y169FDNA_BINDD035Lee HY et al., J Biol Chem 2000Medline
T170IDNA_BINDD036Ribeiro RC et al., J Biol Chem 2001Medline
R172ADNA_BINDD038Ribeiro RC et al., J Biol Chem 2001Medline
R182ADNA_BINDD048Ribeiro RC et al., J Biol Chem 2001Medline
R186ADNA_BINDD052Ribeiro RC et al., J Biol Chem 2001Medline
Y249FLoop 1-3 Lee HY et al., J Biol Chem 2000Medline
S260Loop 1-3 Solomon C et al., Radiat Res 2001Medline
S260ALoop 1-3 Matsushima-Nishiwaki R et al., Cancer Res 2001Medline
S260ALoop 1-3 Dwivedi PP et al., J Biol Chem 2002Medline
S260ALoop 1-3 Matsushima-Nishiwaki R et al., Carcinogenesis 2003Medline
S260DLoop 1-3 Matsushima-Nishiwaki R et al., Cancer Res 2001Medline
I268FLBD HELIX 3335Doyle DF et al., J Am Chem Soc 2001Medline
D273ALBD HELIX 3340Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
D273YLBD HELIX 3340Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
Q275CLBD HELIX 3342Doyle DF et al., J Am Chem Soc 2001Medline
L276ALBD HELIX 3343Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
V280ALBD HELIX 3347Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
E281ALBD HELIX 3348Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
K284ALBD HELIX 3351Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
F289RLoop 3-4 Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L294RLBD HELIX 4448Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L294RLBD HELIX 4448Aarnisalo P et al., J Biol Chem 2002Medline
D295ALBD HELIX 4449Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
Q297ALBD HELIX 4451Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
V298ALBD HELIX 4452Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
I299ALBD HELIX 4453Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L300ALBD HELIX 4454Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L301ALBD HELIX 4455Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
R302ALBD HELIX 4456Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
W305ALBD HELIX 5548Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
N306ALBD HELIX 5549Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L309VLBD HELIX 5552Doyle DF et al., J Am Chem Soc 2001Medline
I310MLBD HELIX 5553Doyle DF et al., J Am Chem Soc 2001Medline
F313ALBD HELIX 5556Zhang J et al., Mol Cell Biol 1999Medline
F313ALBD HELIX 5556Wan H et al., Cancer Res 2001Medline
F313ALBD HELIX 5556Thompson PD et al., J Mol Endocrinol 2001Medline
F313ALBD HELIX 5556Wang M et al., J Mol Graph Model 2003Medline
F313ILBD HELIX 5556Doyle DF et al., J Am Chem Soc 2001Medline
L326FLoop 5-6 Doyle DF et al., J Am Chem Soc 2001Medline
V342FLoop 6-7 Doyle DF et al., J Am Chem Soc 2001Medline
Y397FLBD HELIX 9947Lee HY et al., J Biol Chem 2000Medline
A416LBD HELIX 10-111041Lee SK et al., Mol Endocrinol 1998Medline
A416DLBD HELIX 10-111041Lee SK et al., J Biol Chem 2000Medline
A416DLBD HELIX 10-111041Aarnisalo P et al., J Biol Chem 2002Medline
A416KLBD HELIX 10-111041Lee SK et al., J Biol Chem 2000Medline
A416KLBD HELIX 10-111041Aarnisalo P et al., J Biol Chem 2002Medline
K417LBD HELIX 10-111042Lee SK et al., Mol Endocrinol 1998Medline
L419RLBD HELIX 10-111044Ribeiro RC et al., J Biol Chem 2001Medline
L420RLBD HELIX 10-111045Ribeiro RC et al., J Biol Chem 2001Medline
R421LBD HELIX 10-111046Lee SK et al., Mol Endocrinol 1998Medline
R421ALBD HELIX 10-111046Chen S et al., J Biol Chem 1999Medline
R421ALBD HELIX 10-111046Aarnisalo P et al., J Biol Chem 2002Medline
R421LLBD HELIX 10-111046Lee SK et al., J Biol Chem 2000Medline
R421PLBD HELIX 10-111046Aarnisalo P et al., J Biol Chem 2002Medline
A424LBD HELIX 10-111049Lee SK et al., Mol Endocrinol 1998Medline
R426LBD HELIX 10-111051Lee SK et al., Mol Endocrinol 1998Medline
L430ALBD HELIX 10-111055Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L430FLBD HELIX 10-111055Wan H et al., Cancer Res 2001Medline
K431ALBD HELIX 10-111056Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
K431QLBD HELIX 10-111056Wan H et al., Cancer Res 2001Medline
C432GLBD HELIX 10-111057Doyle DF et al., J Am Chem Soc 2001Medline
L433ALBD HELIX 10-111058Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
E434ALBD HELIX 10-111059Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L436ALBD HELIX 10-111061Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L436VLBD HELIX 10-111061Doyle DF et al., J Am Chem Soc 2001Medline
F437ALoop 11-12 Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
F439LLoop 11-12 Doyle DF et al., J Am Chem Soc 2001Medline
K440ALoop 11-12 Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L441ALoop 11-12 Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
D448ALBD HELIX 121245Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
F450ALBD HELIX 121247Ren Y et al., Mol Cell Biol 2000Medline
F450PLBD HELIX 121247Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L451ALBD HELIX 121248Shao G et al., Mol Endocrinol 2000Medline
L451ALBD HELIX 121248Osburn DL et al., Mol Cell Biol 2001Medline
L451ALBD HELIX 121248Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
E453KLBD HELIX 121250Ren Y et al., Mol Cell Biol 2000Medline
E453KLBD HELIX 121250Osburn DL et al., Mol Cell Biol 2001Medline
M454ALBD HELIX 121251Osburn DL et al., Mol Cell Biol 2001Medline
M454ALBD HELIX 121251Aarnisalo P et al., J Biol Chem 2002Medline
L455ALBD HELIX 121252Osburn DL et al., Mol Cell Biol 2001Medline
L455ALBD HELIX 121252Thompson PD et al., J Mol Endocrinol 2001Medline
L455ALBD HELIX 121252Ghosh JC et al., Proc Natl Acad Sci U S A 2002Medline
L455ALBD HELIX 121252Aarnisalo P et al., J Biol Chem 2002Medline
E456KC-term Ren Y et al., Mol Cell Biol 2000Medline
E456KC-term Osburn DL et al., Mol Cell Biol 2001Medline

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F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005