NucleaRDB: Point mutations extracted from the literature - THB1_MOUSE

2005, NucleaRDB.

This data was extracted from medline abstracts and full text papers (when available) in an automated manner.

Each point mutation is linked to the entry specific to the residue position. Citations are linked to the list of point mutations found in the corresponding articles. The last column allows you to go back to the original text via Medline.

Protein	THB1_MOUSE (Thrb,C-erba-beta, Nr1a)	Swiss-Prot Cross-reference table Family page
Family alignments	1A2 Thyroid hormone beta 1A Thyroid hormone (TR) 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR

Mutation Location General numbering Reference
R243Q Loop 1-3 Yen P et al., Trends Endocrinol Metab 2003 Medline

R243W Loop 1-3 Yen P et al., Trends Endocrinol Metab 2003 Medline

R316H LBD HELIX 5 555 Yen P et al., Trends Endocrinol Metab 2003 Medline

R338W LBD HELIX 6 647 Yen P et al., Trends Endocrinol Metab 2003 Medline

R429Q LBD HELIX 10-11 1051 Yen P et al., Trends Endocrinol Metab 2003 Medline

H435L LBD HELIX 10-11 1057 Yen P et al., Trends Endocrinol Metab 2003 Medline

R438C LBD HELIX 10-11 1060 Liu YY et al., J Biol Chem 2003 Medline

Mutation	Location	General numbering	Reference
R243Q	Loop 1-3		Yen P et al., Trends Endocrinol Metab 2003	Medline
R243W	Loop 1-3		Yen P et al., Trends Endocrinol Metab 2003	Medline
R316H	LBD HELIX 5	555	Yen P et al., Trends Endocrinol Metab 2003	Medline
R338W	LBD HELIX 6	647	Yen P et al., Trends Endocrinol Metab 2003	Medline
R429Q	LBD HELIX 10-11	1051	Yen P et al., Trends Endocrinol Metab 2003	Medline
H435L	LBD HELIX 10-11	1057	Yen P et al., Trends Endocrinol Metab 2003	Medline
R438C	LBD HELIX 10-11	1060	Liu YY et al., J Biol Chem 2003	Medline

F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005