NucleaRDB: Extraction of mutation data from the literature

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This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes different point mutations at a given position and provides links to other documents. The sentence(s) where the point mutations in NR1I3_MOUSE at position 174 were found are listed after the table.

Point mutations at position I174 in NR1I3_MOUSE

ProteinNR1I3_MOUSE (O35627)    Gene: Nr1i3,Ca    (other point mutations)Swiss-Prot
Cross-reference table
Family page
Protein isoforms2
PositionI174
General numbering (NucleaRDB) 338
DomainLBD HELIX 3
Family alignments 1I3 Constitutive Androstane alpha (CAR1)
1I Vitamin D3-like (VDR,PXR,CAR)
1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations at the same position Position 174 in 1I3 Constitutive Androstane alpha (CAR1) family
Position 228 in 1I Vitamin D3-like (VDR,PXR,CAR) family
Position 221 in 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR family
Reference #1Tzameli I, Pissios P, Schuetz EG, Moore DD
Mol Cell Biol 2000 May;20(9):2951-8.		Medline
Text sourceHTML and PDF full texts
Point mutationI174A (True positive)
Reference #2Jyrkkarinne J, Makinen J, Gynther J, Savolainen H, Poso A, Honkakoski P
J Med Chem 2003 Oct 23;46(22):4687-95.		Medline
Text sourceHTML full text
Point mutationI174A (Not yet checked)
Cited point mutationIle174Ala,Ile174

Relevant sentences

Reference #1 (Tzameli I et al.): I174A
  • The plasmid with the F171L mutation was generated first and was then used as a template for the introduction of the I174A mutation

Reference #2 (Jyrkkarinne J et al.): Ile174
  • Other amino acids such as Lys187 and Phe171 plus Ile174 have been shown to affect corepressor binding33 and responsiveness to both TCPOBOP and androstenol , 17 respectively

  • However , because Lys187 is conserved among NRs and it forms a crucial contact with both coactivators and corepressors , 4 , 5 and because the double mutation of Phe171 plus Ile174 to alanine abolished the response to both activating and inhibiting ligands , 17 we interpret that these amino acids have a more global role in mCAR function

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F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005