NucleaRDB: Extraction of mutation data from the literature

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This data was extracted from Medline abstracts and full texts (when available) in an automated manner.

The table below describes different point mutations at a given position and provides links to other documents. The sentence(s) where the point mutations in RORA_HUMAN at position 363 were found are listed after the table.

Point mutations at position A363 in RORA_HUMAN

ProteinRORA_HUMAN (P35398)    Gene: RORA,NR1F1, RZR    (other point mutations)Swiss-Prot
Cross-reference table
Family page
Protein isoforms4
PositionA363
General numbering (NucleaRDB) 342
DomainLBD HELIX 3
Family alignments 1F1 ROR alpha
1F RAR-related orphan receptor (ROR,HR3)
1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR
Other point mutations at the same position Position 330 in 1F1 ROR alpha family
Position 330 in 1F RAR-related orphan receptor (ROR,HR3) family
Position 225 in 1 Thyroid hormone like (TR,RAR,ROR,PPAR,VDR family
Reference #1Kallen J, Schlaeppi JM, Bitsch F, Delhon I, Fournier B
J Biol Chem 2004 Apr 2;279(14):14033-8. Epub 2004 Jan 13.		Medline
Text sourceHTML full text
Point mutationA363L (Not yet checked)
Cited point mutationA330L
Point mutationA363Q (Not yet checked)
Cited point mutationA330Q

Relevant sentences

Reference #1 (Kallen J et al.): A330L
  • The triple mutant A330Q , A371Q , C323L (designed to prevent binding of cholesterol and cholesterol sulfate in the LBP) showed a reduced activity (Fig. 3A ) consistent with the results obtained previously for the single mutants A330L , A371Q , and C323L (3 )

Reference #1 (Kallen J et al.): A330Q
  • The ROR alpha mutants C228Q , A330Q , A371Q , C323L , and K339A , E509A were generated using a QuikChange XL site-directed mutagenesis kit from Stratagene (La Jolla , CA)

  • The triple mutant A330Q , A371Q , C323L (designed to prevent binding of cholesterol and cholesterol sulfate in the LBP) showed a reduced activity (Fig. 3A ) consistent with the results obtained previously for the single mutants A330L , A371Q , and C323L (3 )

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F.Horn (nucleardbcmbi.kun.nl), 21-Apr-2005