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Recent Published Papers
1996-present
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Recent Published Papers 1996-present
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LAB PUBLICATIONS, 1996-PRESENT
Papers (refereed):
121. O Lichtarge, HR Bourne & FE Cohen: An evolutionary trace method defines binding surfaces common to protein families. J. Mol. Biol. 257:342-358, 1996.
122. BR Conklin, P Herzmark, S Ishida, TA Voyno-Yasenetskaya, Y Sun, Z Farfel & HR Bourne: Carboxyl-terminal mutations of Gqa and Gsa that alter the fidelity of receptor activation. Mol Pharmacol 50:885-890, 1996.
123. PB Wedegaertner, HR Bourne & M von Zastrow: Activation-induced subcellular redistribution of Gsa. Mol Biol Cell 7:1225-1233, 1996.
124. TA Voyno-Yasenetskaya, MP Faure, NG Ahn & HR Bourne: Ga12 and Ga13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. J Biol Chem 271:21081-21087, 1996.
125. O Lichtarge, HR Bourne & FE Cohen: Evolutionarily conserved Gabg binding surfaces support a model of the G protein-receptor complex. Proc Natl Acad Sci USA 93:7507-7511, 1996.
126. Z Farfel, T Iiri, H Shapira, Z Roitman, M Mouallem & HR Bourne: Pseudohypoparathyroidism, a novel mutation in the bg-contact region of Gsa impairs receptor stimulation. J Biol Chem 271:19653-19655, 1996.
127. SP Sheikh, TA Zvyaga, O Lichtarge, TP Sakmar & HR Bourne: Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 383:347-350, 1996.
128. T Iiri, PB Backlund, TLZ Jones, PB Wedegaertner & HR Bourne: Reciprocal regulation of Gsa by palmitate and the bg subunit. Proc Natl Acad Sci USA 93:14592-14597, 1996.
129. R Onrust, P Herzmark, P Chi, PD Garcia, O Lichtarge, C Kingsley & HR Bourne: Receptor and bg binding sites in the a subunit of the retinal G protein transducin. Science 275:381-384, 1996.
130. Y Yan, PP Chi & HR Bourne: RGS4 inhibits Gq-mediated activation of mitogen-activated protein kinase and phosphoinositide synthesis. J Biol Chem 272:11924-11927, 1997.
131. T Iiri, Z Farfel & HR Bourne: Conditional activation defect of a human Gsa mutant. Proc Natl Acad Sci USA 94:5656-5661, 1997.
132. J Morales, CS Fishburn, PT Wilson & HR Bourne: Plasma membrane localization of Gaz requires two signals. Mol Biol Cell 9:1-14, 1998.
133. ER Neptune & HR Bourne: Receptors induce chemotaxis by releasing the bg subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci USA 94:14489-14494, 1997.
134. DM Apanovitch, T Iiri, T Karasawa, HR Bourne & HG Dohlman: Second site suppressor mutations of a GTPase-deficient G-protein a subunit: Selective inhibition of Gbg-mediated signaling. J Biol Chem 273:28597-28602, 1998.
135. ER Neptune, T Iiri & HR Bourne: Gai is not required for chemotaxis mediated by Gi-coupled receptors. J Biol Chem 274:2824-2828, 1999.PDF
136. T Iiri, SM Bell, TJ Baranski, T Fujita & HR Bourne: A Gsa mutant designed to inhibit receptor signaling through Gs. Proc Natl Acad Sci U S A 96:499-504, 1999..PDF
137. G Servant, OD Weiner, ER Neptune, JW Sedat & HR Bourne: Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell 10:1163-1178, 1999.PDF
138. TJ Baranski, P Herzmark, O Lichtarge, BO Gerber, J Trueheart, EC Meng, T Iiri, SP Sheikh & HR Bourne: C5a receptor activation: Genetic identification of critical residues in four transmembrane helices. J Biol Chem 274:15757-15765, 1999.PDF
139. SP Sheikh, J Villardarga, TJ Baranski, O Lichtarge, T Iiri, EC Meng, RA Nissenson & HR Bourne: Similar structures and shared switch mechanisms of the b2 adrenoceptor and the parathyroid hormone receptor: Zn(II) bridges between helices III and VI block activation. J Biol Chem 274:17033-17041, 1999.PDF
140. CS Fishburn, P Herzmark, J Morales & HR Bourne: Gbg and palmitate target newly synthesized Gaz to the plasma membrane. J Biol Chem 274:18793-18800, 1999.PDF
141. OD Weiner, G Servant, MD Welch, TJ Mitchison, JW Sedat & HR Bourne: Spatial control of actin polymerization during neutrophil chemotaxis. Nature Cell Biology 1:75-81, 1999.PDF
142. CS Fishburn, SK Pollitt & HR Bourne: Localization of a peripheral membrane protein: Gbg targets Gaz. Proc Natl Acad Sci USA 97:1085-1090, 2000.PDF
143. G Servant, OD Weiner, P Herzmark, T Balla, JW Sedat & HR Bourne: Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 287:1037-1040, 2000.PDF
144. BO Gerber, EC Meng, V Dötsch, TJ Baranski & HR Bourne: An activation switch in the ligand binding pocket of the C5a receptor. J Biol Chem 276:3394-3400, 2001.PDF
145. P Rondard, T Iiri, S. Srinivasan, E Meng, T Fujita, HR Bourne: Mutant G protein a subunit activated by Gb g : a model for receptor activation? Proc Natl Acad Sci 98:6150-6155, 2001.PDF
146. O. D. Weiner, P. O. Neilsen, G. D. Prestwich, M. W. Kirschner, L. C. Cantley and H. R. Bourne. A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nature Cell Biology 4:509-512, 2002.PDF
147. F. Wang, P. Herzmark, O. D. Weiner, S. Srinivasan, G. Servant and H. R. Bourne. Lipid products of phosphoinositide 3-kinases maintain persistent cell polarity and directed motility in neutrophils. Nature Cell Biology 4:513-518, 2002. PDF
148. J. L. Whistler, B. O. Gerber, E. C. Meng, T. J. Baranski, M. Von Zastrow and H.R. Bourne. Con-stitutive Activation and Endocytosis of the Complement Factor 5a Receptor: Evidence for Mul-tiple Activated Conformations of a G protein-Coupled Receptor. Traffic 3:866, 2002. PDF
149. Yu, W., O'Brien, L. E., Wang, F., Bourne, H. R., Mostov, K. E., and Zegers, M. Hepatocyte Growth factor switches orientation of polarity and mode of motility during morphogenesis of multicellular epithelial structures. Mol Biol Cell, 14:748-763, 2002. PDF
150. Srinivasan, S., Wang, F., Glavas, S., Ott, A., Hofmann, F., Aktories,K., Kalman, D., and Bourne, H. R.(2003) Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol 160:375-385, 2003. PDF
151. Xu, J., F. Wang, A. Van Keymeulen, P. Herzmark, A. Straight, K. Kelly, T. Mitchison, and H.R. Bourne, Divergent signals and cytoskeletal assemblies explain self-organizing polarity in neutrophils. Cell (2003)114:201-214. PDF
152 Buck, E., H.R. Bourne, and J. A. Wells, Site-specific Disulfide Capture of Agonist and Antagonist Peptides on the C5a Receptor. J. Biol. Chem., Feb 2005; 280: 4009 - 4012 PDF
Reviews (Refereed):
6. T Iiri, Z Farfel & HR Bourne: G-protein diseases furnish a model for the turn-on switch. Nature 394:35-38, 1998.
7. Z Farfel, HR Bourne & T Iiri: Mechanisms of disease: The expanding spectrum of G protein diseases. N Engl J Med 340:1012-1020, 1999
8. P Rickert, OD Weiner, F Wang, HR Bourne &G Servant: Leukocytes navigate by compass: roles of PI3Kg and its lipid products. Trends in Cell Biol 10:466-473, 2000.
9. HR Bourne & EK OÕShea: Editors of Cell regulation issue. Current Opinion in Cell Biology v.14 no. 2, 2002.
10. Sambrano GR, Chandy G, Choi S, DeCamp D, Hsueh R, Lin K-M, O'Rourke N, Roach T, Shu H, Sinkovits B, Verghese M, & Bourne H. Unravelling the signal-transduction network in B lymphocytes. Nature (In Press) 2002.
Reviews/Chapters in Books (not refereed)
84. HR Bourne, P Garcia, R Onrust, Y Yan, O Lichtarge & FE Cohen: G protein activation by 7TM receptors–a progress report. Munksgaard, Copenhagen, Denmark, Structure and Function of 7TM Receptors. Alfred Benzon Symposium 39, 32-42, 1996.
85. HR Bourne: How receptors talk to trimeric G proteins. IN Current Opinion in Cell Biology. LC Cantley & SR Coughlin, (ed.). Vol. 9, No. 2, pp. 134-142, Current Biology, Ltd., London, 1997.
86. HR Bourne: The arginine finger strikes again. Nature 389:673-674, 1997.
87. HR Bourne: Drug Receptors & Pharmacodynamics (Chap. 2). IN Basic and Clinical Pharmacology, 7th Edition, BG Katzung (ed.), Appleton & Lange, Stamford, Connecticut, pp. 9-33, 1997.
88. T Iiri & HR Bourne: G proteins propel surprise. Nature Genetics 18:8-10, 1998.
89. HR Bourne: Pieces of the true grail: A G protein finds its target. Science 278:1898-1899, 1997.
90. HR Bourne: A necessary hero. Curr Biol 9:R870-R871, 1999.
91. OD Weiner, G Servant, CA Parent, PN Devreotes & HR Bourne: Cell polarity in response to chemoattractants. IN Cell Polarity: Frontiers in Molecular Biology. DG Drubin, (ed.). Oxford University Press, 2000.
92. HR Bourne & EC Meng: Rhodopsin sees the light. Science 289: 733-734, 2000.
93. HR Bourne and OD Weiner: A chemical compass. Nature 419: 21, 2002.
94. GR Sambrano, G Chandy, S Choi, D Decamp, R Hsueh, KM Lin, D Mock, N O'Rourke, T Roach, H Shu, B Sinkovits, M Verghese, H Bourne: Unravelling the signal-transduction net-work in B lymphocytes. Nature 420:708-10, 2002
Last updated on 7/8/2004