Novel Heterocyclic Pharmacotherapies for Prion Disease
Publications:
May, B. C. H., Cohen, F. E., Prusiner, S. B., Korth, C. "Heterotricyclic antiprion compounds: acridines and phenothiazines." In, Transmissible Spongiform Encephalopathies: New Perspectives for Prion Therapeutics, Conference Proceedings, Paris, Dec 1-3, 2002, ed. Lehmann, S.
May, B. C. H., Cohen, F. E., Prusiner, S. B., Korth, C. "Heterotricyclic antiprion compounds: acridines and phenothiazines." In Press.
Prusiner, S. B., May, B.C.H., and Cohen, F.E. "Therapeutic approaches to prion diseases." In Prion Biology and Diseases, Second Edition (S.B. Prusiner, ed.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. In Press
May, B. C. H., Fafarman, A. T., Hong, S. B., Rogers, M., Deady, L. W., Prusiner, S. B., Cohen, F. E. "Potent Inhibition of Scrapie Prion Protein Replication in Cultured Cells by Bis-Acridines." (2003) Proceedings of the National Academy of Science, U.S.A. 100, 3416.
May, B. C. H.,Abell, A. D. "a-Methylene tetrazole-based peptidomimetics: synthesis and inhibition of HIV protease." (2002), Journal of the Chemical Society, Perkin Transactions 1, 2, 172.
Abell, A. D., Martyn, D. C.; May, B. C. H., Nabbs, B.
K. "An amino acid N-derivatising group that can be coloured on
demand." (2002), Tetrahedron Letters, 43, 3673.
Korth, C., May, B. C. H., Cohen, F. E. and Prusiner,
S. B. "Acridine and Phenothiazine Derivatives as Pharmacotherapies
for Prion Disease." (2001) Proceedings of the National Academy
of Science, U.S.A. 98, 9836.
May, B. C. H. and Abell, A. D. "The Synthesis
and Solid State Structure of (8S)-8-Benzyl-8,9-dihydro-7H-tetrazolo[1,5,d][1,4]diazepin-6-one."
(2001) Chemical Communications, 2080.
May, B. C. H. and Abell, A. D. "The Synthesis
and Crystal Structure of Alpha-keto Tetrazole-based Dipeptide Mimics."
(2001) Tetrahedron Letters, 42, 5641.
Abell, A. D., May, B. C. H. and Nabbs, B. K. "An
Amino Acid Protecting Group That Can Be Colored on Demand."
(2000) Peptides: Proceedings of the Twenty-Sixth European Peptide Symposium,
(Ed. J. Martinez, J.-A. Fehrentz) 285.
May, B. C. H. and Abell, A. D. "A Convenient
Preparation of (2RS,3S)3-Amino-2-hydroxy-4-phenylbutanoic Acid; An Important
Peptide Bond Isostere." (1999) Synthetic Communications, 29,
2515.
Abell, A. D., Edmonds, M. K. and May, B. C. H. "The
Synthesis of Conformationally Restricted HIV Protease Inhibitors."
(1998) Russian Journal of AIDS and Related Problems, 2, 74.
Lorimer, S. D., Barns, G., Evans A. C., Foster, L. M., May, B.
C. H., Perry, N. B. and Tangney, R. S. "Cytotoxicity
and Antimicrobial Activity of Plants from New Zealand's Subantarctic Islands."
(1996) Phytomedicine, 2, 327.
Perry, N. B., Foster, L. M., Lorimer, S. D. and May, B. C. H.
"Isoprenyl Phenyl Ethers from the Liverwort of the Genus Trichocolea:
Cytotoxic Activity, Structural Corrections, and Synthesis."
(1996) Journal of Natural Products, 39, 729.