Cedric Govaerts, Ph.D
Postdoctoral Fellow
Department of Cellular & Molecular Pharmacology
University of California, San Francisco
600 16th Street, N476 ( Box 2240 )
San Francisco, CA 94143-2240
 
Phone: (415) 502-5650
Fax: (415) 476-6515
Email: cedric@cmpharm.ucsf.edu
Home Page
 
RESEARCH: Modelling The Pathological Conformation Of The Prion Protein
 
EDUCATION
1995 :
 Master in Physical Science at the Université Libre de Bruxelles (ULB).
2001 :
 PhD Thesis in Structural Biology at the ULB.
  Title “Study of the activation mechanisms of the G-protein coupled receptors using Molecular Modeling”. Advisors were Prof. G. Vassart (IRIBHN, ULB, Brussels) and S. Wodak (Service de Conformation des Macromolécules Biologiques, ULB, Brussels).
2001 :
Post-doctoral contract at the ULB, Brussels.
2002 :
 Post-doctoral training at University of California San Francisco.
 
PUBLICATIONS
 
Claeysen S, Govaerts C, Lefort A, Van Sande J, Costagliola S, Pardo L, Vassart G.
A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist. FEBS Lett. 2002 Apr 24;517(1-3):195-200.
Olivella M, Deupi X, Govaerts C, Pardo L. Influence of the Environment in the Conformation of a-Helices Studied by Protein Database Search and Molecular Dynamics Simulations. Biophys J. 2002 Jun;82(6):3207-13.
Smits G, Govaerts C, Nubourgh I, Pardo L, Vassart G, Costagliola S. Lysine 183 and glutamic acid 157 of the thyrotropin receptor : two interacting residues with a key role in determining specificity towards tsh and hCG. Mol Endocrinol. 2002 Apr 1;16(4):722-35.
Blanpain C, Wittamer V, Vanderwinden JM, Boom A, Renneboog B, Lee B, Le Poul E, El Asmar L, Govaerts C, Vassart G, Doms RW, Parmentier M. Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways. J Biol Chem. 2001 Jun 29;276(26):23795-804.
Govaerts C, Lefort A, Costagliola S, Wodak SJ, Ballesteros JA, Van Sande J, Pardo L, Vassart G. A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor. J Biol Chem. 2001 Jun 22;276(25):22991-9.
Govaerts C, Blanpain C, Deupi X, Ballet S, Ballesteros JA, Wodak SJ, Vassart G, Pardo L, Parmentier M. The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation. J Biol Chem. 2001 Apr 20;276(16):13217-25.
Blanpain C, Doranz BJ, Vakili J, Rucker J, Govaerts C, Baik SS, Lorthioir O, Migeotte I, Libert F, Baleux F, Vassart G, Doms RW, Parmentier M. Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein. J Biol Chem. 1999 Dec 3;274(49):34719-27.
Jamieson CR, Govaerts C, Abramowicz MJ. Primary autosomal recessive microcephaly: homozygosity mapping of MCPH4 to chromosome 15. Am J Hum Genet. 1999 Nov;65(5):1465-9. No abstract available.
Blanpain C, Migeotte I, Lee B, Vakili J, Doranz BJ, Govaerts C, Vassart G, Doms RW, Parmentier M. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999 Sep 15;94(6):1899-905.
Blanpain C, Lee B, Vakili J, Doranz BJ, Govaerts C, Migeotte I, Sharron M, Dupriez V, Vassart G, Doms RW, Parmentier M. Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity. J Biol Chem. 1999 Jul 2;274(27):18902-8.
Rodien P, Cetani F, Costagliola S, Tonacchera M, Duprez L, Minegishi T, Govaerts C, Vassart G. Evidences for an allelic variant of the human LC/CG receptor rather than a gene duplication: functional comparison of wild-type and variant receptors. J Clin Endocrinol Metab. 1998 Dec;83(12):4431-4.
Erneux C, Govaerts C, Communi D, Pesesse X. The diversity and possible functions of the inositol polyphosphate 5-phosphatases. Biochim Biophys Acta. 1998 Dec 8;1436(1-2):185-99.
Samson M, Edinger AL, Stordeur P, Rucker J, Verhasselt V, Sharron M, Govaerts C, Mollereau C, Vassart G, Doms RW, Parmentier M. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Eur J Immunol. 1998 May;28(5):1689-700.
Communi D, Govaerts C, Parmentier M, Boeynaems JM. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. J Biol Chem. 1997 Dec 19;272(51):31969-73.
 
 

 

 

 

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