Lawrence Lee
UCSF Genentech Hall MC 2240
600 16th St
San Francisco, CA 94158
lawrence.lee@cmpharm.ucsf.edu

Education:

2001-Present
University of California, San Francisco, Ph.D. program, Biological and Medical 
Informatics.  Thesis topic: Text Mining of Point Mutation Information from Biomedical 
Literature and Protein Family Analysis.
Principal Investigator: Fred E. Cohen 
1996-2000
University of California, Berkeley, B.A., Molecular and Cell Biology, emphasis in 
Biochemistry.

Research Experience:

Present
Graduate Student, Cohen Lab, University of California, San Francisco.  Using 
computation methods to identify and extract point mutation information from biomedical 
literature to create mutational databases for protein families.  Analysis of residues in 
protein families within framework of point mutation significance.
1998-2000
Undergraduate Researcher, Kane Lab, University of California, Berkeley.  Project titled 
"Characterization of Fcp1, a Yeast CTD Phosphatase".  Cloned Fcp1 and mutants of 
Fcp1 into expression vectors, purified proteins from bacterial expression, and assayed 
proteins for phosphatase activity in vitro.  

Work Experience:

2000-2001
Bioinformatics Associate, DNA Sciences, Inc., Fremont, CA.  Assisted experimental 
design in genotyping lab to ensure data flow.  Developed tools to automate high-
throughput SNP and microsatellite analysis.  

Awards/Fellowships:

1999
Howard Hughes Medical Institute Biology Fellows Scholar
2006
NIH/NLM Individual Bioinformatics Fellowship

Publications:

1.	Lee LC, Horn F, Cohen FE (2007) Automatic Extraction of Protein Point Mutations Using a Graph 
Bigram Association. PLoS Comput Biol 3(2): e16 doi:10.1371/journal.pcbi.0030016

Presentations:

1.	Presentation, "Extraction of Functional Point Mutation Information from Biomedical Literature", 
NLM/NIH Training Conference 2007
2.	Poster, "Analysis of Cystic Fibrosis Associated Mutations Using Text-Mining of Journal Literature", 
PSB 2007 
3.	Poster, "Computational Extraction of Point Mutations from Biomedical Literature, NLM/NIH Training 
Conference 2006
4.	Poster, "MutationMiner: A Graph Theoretic Approach to Extract Point Mutation Information from 
Biomedical Literature", ISMB 2003